Help fixing Okami

Hi, I'm new here, so hopefully this isn't a painfully obvious solution, but it's really been bugging me. So I've been trying to emulate Okami, but I'm experiencing random crashes every 15-20 minutes of gameplay. When the game is running, it works fine, and I'm getting a solid 60 FPS with no hiccups or graphical errors, and when it crashes, there's no warning whatsoever. I've tried turning off speedhacks so far, but that hasn't solved my problem. My specs are:

Intel Core i7 @ 2.50 GHz
16.0 GB RAM
AMD Radeon R5 M335

Any help would be appreciated. Thanks!